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Engineered coral, an optimal scaffold for tissue engineering of bone.

Locatie: Noutati // Data: 14.02.2018

Engineered coral, an optimal scaffold for tissue engineering of bone.

I. BINDERMAN1 & A. Yaffe2. 1Department of Oral Biology, Maurice and Gabriela Goldschleger School of Dental Medicine, 'Sackler' Faculty of Medicine, Tel Aviv University, and 2Haddasah School of Dental Medicine, Hebrew University, Jerusalem.

 

Introduction: Generation of bone is the challenge faced by current technologies in tissue engineering, depending highly on bioactive scaffolds and osteoprogenitors. An early cell-scaffold interaction is a crucial determinate to initiate a sequence of cellular and molecular events activating osteogenic pathway. Calcium carbonate in the form of Aragonite crystals, the exoskeleton of coral from sea origin was shown to be a passive scaffold allowing bone to form in close proximity to this mineral.

 

Our Aim : was to modify the exoskeleton mineral of coral during its growth in aquariums by incorporating silicium in its intrinsic structure, during growth. The silicium enriched coral mineral scaffold was tested for its activity to attract osteoprogenitors on its surface producing bone directly on the coral mineral surface.

 

Methods: Our DA rat model was employed to test osteogenesis when modified coral was mixed with fresh marrow at thoracic ectopic site(Bahar et al, 2010).

                                                

In conclusion: we demonstrate that corals grown in aquariums under controlled light and sea medium conditions is transformed into a most bioactive scaffold for engineering of bone.

This study is supported by IGF fund to CorBone ltd, Tel Aviv

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